National Symposium on HIV/AIDS Prevention & Transmission 2007, you will hear from experts from universities throughout the US and from South Africa, updating us on their latest research and findings. Join Eliezer Masliah, MD, University of California, San Diego, as he presents on Changing Aspects of the Neuropathogenesis of HIV in the HAART Era.
Showing posts with label HIV. Show all posts
Showing posts with label HIV. Show all posts
Sunday, December 14, 2008
Saturday, December 13, 2008
AIDS and the HIV Life Cycle
Aids and HIV Life cycle lecture was given by Dr.Bruce Walker ,He is Howard Hughes Medical Institute Investigator,and Director for Center for AIDS Research at Harvard University.The lecture starts from HIV structure , various component of HIV virus,Mechanism of HIV , and how HIV causes AIDS,He also talks about why our immune system is unable to stop HIV virus.The lecture uses various case studies of show HIV variability,he also talk about various challenges for designing drugs for HIV .
If u wanna Download this Video, u can do this here
This lecture explain about HIV manifestation,
Hiv was first found among few gay persons in califonia,it later spread all aroung USA,
This virus are essentially packages of genetic material and are not able to replicate on their won ,But they carry all the information acquired for replication
if you had chickenpox or infectious mono as child you have that virus still alive in your body now the reason it's not causing diseases that you have an effective immune response that it will help you to keep it in check now
when you first became infected with chickenpox you felt really lousy .The part of that feeling of lousy as your immune system trying to respond and fight the invading pathogen and ultimately even though the virus persists in your body you enter into a phase where your a symptomatic and the virus is not causing any problems again with immune system keeping in check
Early symptoms for Aids Patient had fever, chills, shaking, Headache at times loss of appetite joint and muscle pain and malaise skin rashes,and swollen lymph nodes .
It takes more than 3 weeks produce Hiv Antibody
polymerase chain reaction helps to directly quantitative the amount of virus in the bloodstream
people have a transient drop in Cd4 helper cell counts and then T-helper cell levels decline slowly over time until the ultimate development of AIDS.
HIV it's a typical retrovirus ,meaning that it has in outer envelope. in the center it has two copies of RNA as well as an reverse transcriptase Enzyme, which will ultimately turn that RNA into DNA,
The first step in HIV1 life cycle is viral attachment to the CD4 T-cell surface the next step is viral entry which involves a cascade of molecular interactions between the viral envelope glycoprotein and Two T-cell surface receptors a primary receptor and a co-receptor.
The GP 120 subunit of the envelope protein first binds the CD4 primary receptor this induces a conformational change in GP 120 This allows to binds to the co- receptor binding triggers conformational changes in the GP 41 subunit leading to insertion of its N-terminal fusion peptide into the host cell's membrane
If u wanna Download this Video, u can do this here
This lecture explain about HIV manifestation,
Hiv was first found among few gay persons in califonia,it later spread all aroung USA,
This virus are essentially packages of genetic material and are not able to replicate on their won ,But they carry all the information acquired for replication
if you had chickenpox or infectious mono as child you have that virus still alive in your body now the reason it's not causing diseases that you have an effective immune response that it will help you to keep it in check now
when you first became infected with chickenpox you felt really lousy .The part of that feeling of lousy as your immune system trying to respond and fight the invading pathogen and ultimately even though the virus persists in your body you enter into a phase where your a symptomatic and the virus is not causing any problems again with immune system keeping in check
Early symptoms for Aids Patient had fever, chills, shaking, Headache at times loss of appetite joint and muscle pain and malaise skin rashes,and swollen lymph nodes .
It takes more than 3 weeks produce Hiv Antibody
polymerase chain reaction helps to directly quantitative the amount of virus in the bloodstream
people have a transient drop in Cd4 helper cell counts and then T-helper cell levels decline slowly over time until the ultimate development of AIDS.
HIV it's a typical retrovirus ,meaning that it has in outer envelope. in the center it has two copies of RNA as well as an reverse transcriptase Enzyme, which will ultimately turn that RNA into DNA,
The first step in HIV1 life cycle is viral attachment to the CD4 T-cell surface the next step is viral entry which involves a cascade of molecular interactions between the viral envelope glycoprotein and Two T-cell surface receptors a primary receptor and a co-receptor.
The GP 120 subunit of the envelope protein first binds the CD4 primary receptor this induces a conformational change in GP 120 This allows to binds to the co- receptor binding triggers conformational changes in the GP 41 subunit leading to insertion of its N-terminal fusion peptide into the host cell's membrane
Lecture on Vaccines and HIV Evolution
Lecture was giver by Dr.Bruce.D.Walker from Howard Hughes Medical Institute,Topic is Vaccines and HIV Evolution.some of important points from the lecture.About 33 million people are currently infected by HIVof this 90% of people are living in Developing countries
How vaccine works
* Preventing infection (sterilizing immunity).
* Prevent disease (but doesn't prevent infection) by keeping the microbe or its toxins in check (non-sterilizing immunity).
* Goal of the vaccine is to alleviate symptoms and stem transmission.
When B-cells exposed to pathogen are converted into plasma cell and starts to secreate antibodies who job is directly neutralizes virus by binding to outer surface of the virus cell.
Aim of vaccine is to trick the B-cells in thinking that are seeing pathogen,so that they start making antibodies that will prevent future infection.
Possible vaccine
* Killed Virus
* Live attenuated Virus
* Recombinant protein
* Recombinant Virus
Reasons for non availability HIV vaccine
* HIV Reverse trascriptase makes frequent errors during replication
* Sequence variation leads to escape from antibodies and CTL(cytotoxic T-cells) responses
* Loss of CD4 cells leaves immune system unable to respond effectively to newly emerging Mutants.
* GP120 envelope protein undergoes lot of mutation which in turn makes the gp120 structure differnt,Because of this antibodies are unable to bind with HIV virus.
Hiv Vaccine Marveck
On 21 September 2007, the pharmaceutical giant Merck called a halt to a phase II trial of a new vaccine candidate against HIV . An interim assessment showed that the vaccine, long considered the most promising in development, failed both in preventing HIV infection and in reducing the viral load of those infected.The vaccine candidate (Merck V520) is a mixture of three components, each a weakened adenovirus vector carrying one of the three synthetic HIV genes gag, pol and nef. The vaccine is designed to elicit a cell-mediated immune response, to stimulate the body’s own CD8 T-cells that recognize and kill the HIV-infected cells.
How vaccine works
* Preventing infection (sterilizing immunity).
* Prevent disease (but doesn't prevent infection) by keeping the microbe or its toxins in check (non-sterilizing immunity).
* Goal of the vaccine is to alleviate symptoms and stem transmission.
When B-cells exposed to pathogen are converted into plasma cell and starts to secreate antibodies who job is directly neutralizes virus by binding to outer surface of the virus cell.
Aim of vaccine is to trick the B-cells in thinking that are seeing pathogen,so that they start making antibodies that will prevent future infection.
Possible vaccine
* Killed Virus
* Live attenuated Virus
* Recombinant protein
* Recombinant Virus
Reasons for non availability HIV vaccine
* HIV Reverse trascriptase makes frequent errors during replication
* Sequence variation leads to escape from antibodies and CTL(cytotoxic T-cells) responses
* Loss of CD4 cells leaves immune system unable to respond effectively to newly emerging Mutants.
* GP120 envelope protein undergoes lot of mutation which in turn makes the gp120 structure differnt,Because of this antibodies are unable to bind with HIV virus.
Hiv Vaccine Marveck
On 21 September 2007, the pharmaceutical giant Merck called a halt to a phase II trial of a new vaccine candidate against HIV . An interim assessment showed that the vaccine, long considered the most promising in development, failed both in preventing HIV infection and in reducing the viral load of those infected.The vaccine candidate (Merck V520) is a mixture of three components, each a weakened adenovirus vector carrying one of the three synthetic HIV genes gag, pol and nef. The vaccine is designed to elicit a cell-mediated immune response, to stimulate the body’s own CD8 T-cells that recognize and kill the HIV-infected cells.
Subscribe to:
Posts (Atom)
