Anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicyclomine. Generally speaking, it reduces the effects mediated by acetylcholine on acetylcholine receptors in neurons through competitive inhibition. The effect is therefore reversible.
Mechanism of action causing Bronchodilatation
By blocking parasympatc neruo transmittor acetocholine ,anti-cholorinergic drugs promote bronchoconstrictiction,the vagus nerve along the airways release acetylcholine which binds with muscarinic receptors in the smooth muscle and airway sub mucosal glands,by blocking acetylcholine anticholiergics contradict bronchoconstriction
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Showing posts with label Smooth muscle. Show all posts
Showing posts with label Smooth muscle. Show all posts
Wednesday, June 3, 2009
Sunday, December 14, 2008
Contraction in Smooth vs. Skeletal Muscle
Smooth muscle
Smooth muscle is a type of non-striated muscle, found within the tunica media layer of large and small arteries and veins, the bladder, uterus, male and female reproductive tracts, gastrointestinal tract, respiratory tract, the ciliary muscle, and iris of the eye. The glomeruli of the kidneys contain a smooth muscle-like cell called the mesangial cell. Smooth muscle is fundamentally different from skeletal muscle and cardiac muscle in terms of structure, function, excitation-contraction coupling, and mechanism of contraction.
* Cystolic Ca2+ binds with calmodulin in cytosol
* Ca2+ calmodulin complex binds to myosin light chani kinase
* myosin light chain kinase used ATP to phosphorylate myosin cross bridges.
* Phosphorylated cross bridges bind to action filaments
* Cros-bridge cycle produces tension and shortening
Skeletal muscle
Skeletal muscle is a type of striated muscle, which usually attaches to tendons. Skeletal muscles are used to create movement, by applying force to bones and joints; via contraction. They generally contract voluntarily (via somatic nerve stimulation), although they can contract involuntarily through reflexes. The whole muscle is wrapped in a special type of connective tissue, epimysium.
* Cytosolic ca3+
* ca 2+binds to troponin on the filaments
* Conformatioal change in troponinm moves tropomyosin out of blocking position
* Mysosin cross bridges bund to action
* Cross-bridge cycle produces tension and shortening
Smooth muscle is a type of non-striated muscle, found within the tunica media layer of large and small arteries and veins, the bladder, uterus, male and female reproductive tracts, gastrointestinal tract, respiratory tract, the ciliary muscle, and iris of the eye. The glomeruli of the kidneys contain a smooth muscle-like cell called the mesangial cell. Smooth muscle is fundamentally different from skeletal muscle and cardiac muscle in terms of structure, function, excitation-contraction coupling, and mechanism of contraction.
* Cystolic Ca2+ binds with calmodulin in cytosol
* Ca2+ calmodulin complex binds to myosin light chani kinase
* myosin light chain kinase used ATP to phosphorylate myosin cross bridges.
* Phosphorylated cross bridges bind to action filaments
* Cros-bridge cycle produces tension and shortening
Skeletal muscle
Skeletal muscle is a type of striated muscle, which usually attaches to tendons. Skeletal muscles are used to create movement, by applying force to bones and joints; via contraction. They generally contract voluntarily (via somatic nerve stimulation), although they can contract involuntarily through reflexes. The whole muscle is wrapped in a special type of connective tissue, epimysium.
* Cytosolic ca3+
* ca 2+binds to troponin on the filaments
* Conformatioal change in troponinm moves tropomyosin out of blocking position
* Mysosin cross bridges bund to action
* Cross-bridge cycle produces tension and shortening
Anticholinergics
Anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicyclomine. Generally speaking, it reduces the effects mediated by acetylcholine on acetylcholine receptors in neurons through competitive inhibition. The effect is therefore reversible.
Blog contains more than 450 videos covering all the aspects of Biological Sciences
Anticholinergics
Anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicyclomine. Generally speaking, it reduces the effects mediated by acetylcholine on acetylcholine receptors in neurons through competitive inhibition. The effect is therefore reversible.
Mechanism of action causing Bronchodilatation
By blocking parasympatc neruo transmittor acetocholine ,anti-cholorinergic drugs promote bronchoconstrictiction,the vagus nerve along the airways release acetylcholine which binds with muscarinic receptors in the smooth muscle and airway sub mucosal glands,by blocking acetylcholine anticholiergics contradict bronchoconstriction.
Blog contains more than 450 videos covering all the aspects of Biological Sciences
Anticholinergics
Anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicyclomine. Generally speaking, it reduces the effects mediated by acetylcholine on acetylcholine receptors in neurons through competitive inhibition. The effect is therefore reversible.
Mechanism of action causing Bronchodilatation
By blocking parasympatc neruo transmittor acetocholine ,anti-cholorinergic drugs promote bronchoconstrictiction,the vagus nerve along the airways release acetylcholine which binds with muscarinic receptors in the smooth muscle and airway sub mucosal glands,by blocking acetylcholine anticholiergics contradict bronchoconstriction.
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